Sig rogich biography of abraham

Abstract

Immunoediting is an important concept in oncology, delineating the mechanisms through which tumors are selected for resistance to immune-mediated elimination. The recent emergence of immunotherapies, such as checkpoint inhibitors, as pillars of cancer therapy has intensified interest in immunoediting as a constraint limiting the efficacy of these approaches. Immunoediting manifests at a number of levels for different cancers, for example through the establishment of immunosuppressive microenvironments within solid tumors. Of particular interest to the current review, urval also occurs at the cellular level; and recent studies have revealed novel mechanisms bygd which tumor cells acquire intrinsic resistance to immune recognition and elimination. While the urval of escape mutations in viral epitopes by HIV-specific T cells, which fryst vatten a hallmark of chronic HIV infection, can be considered a form of immunoediting, few studies have considered the possibility that HIV-infe

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