Noemi matsutani biography
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Abstract
Glioblastoma (GBM) is the most aggressive primary brain tumor, with a median survival at diagnosis of 16–20 months. Metabolism represents a new attractive therapeutic target; however, due to high intratumoral heterogeneity, the application of metabolic drugs in GBM is challenging. We characterized the basal bioenergetic metabolism and antiproliferative potential of metformin (MF), dichloroacetate (DCA), sodium oxamate (SOD) and diazooxo-L-norleucine (DON) in three distinct glioma stem cells (GSCs) (GBM18, GBM27, GBM38), as well as U87MG. GBM27, a highly oxidative cell line, was the most resistant to all treatments, except DON. GBM18 and GBM38, Warburg-like GSCs, were sensitive to MF and DCA, respectively. Resistance to DON was not correlated with basal metabolic phenotypes. In combinatory experiments, radiomimetic bleomycin exhibited therapeutically relevant synergistic effects with MF, DCA and DON in GBM27 and DON in all other cell lines. MF and DCA shifted the metabolism
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Content type: ResearchPublished on: 22 February
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Noémi Domokos was born in Satu Mare, Rumania, otherwise known as Transylvania. The daughter of a Lithuanian mother and a Hungarian father grew up in Germany and Southern California, where a large part of her family lives. She studied ballet at the Royal Academy of Dance and made her stage debut with the dance group Bubblegum and Roses.
An injury caused her to change her career but she stayed on the stage: after graduation from acting school she appeared in diverse theater productions, including an acclaimed performance as Helena in Shakespeare's Midsummer Night's Dream. Noémi made her film debut in the psycho-thriller Die Stimmen (Voices), which was a huge ratings success.
She starred in the TV Event Movie Faktor 8 in which she played the heroic flight attendant Petra, who desperately tries to protect her passengers from a deadly disease on board the plane.
In she starred in the Comedy "Der Vollgasmann", playing tough media coach Kiera Jansen, who worships Chi